Monday, November 24, 2008

Tuesday, November 18, 2008

Does the key to the cure lie within genetics? pretty interesting bbc article

Bone marrow 'cures HIV patient'


Doctors in Germany say a patient appears to have been cured of HIV by a bone marrow transplant from a donor who had a genetic resistance to the virus.

The researchers in Berlin said the man, who suffered from leukaemia and HIV, had shown no sign of either disease since the transplant two years ago.

But they stressed it was an unusual case which needed further investigation.

Experts said the result may boost interest in gene therapy for HIV.

Berlin's Charite clinic said the 42-year-old patient was an American living in Berlin, but the man has not been identified.

Genetic mutation

He had been infected with the human immunodeficiency virus, that causes Aids, for more than a decade and also had leukaemia.

The clinic said since the transplant was carried out 20 months ago, tests on the patient's bone marrow, blood and other organ tissues have all been clear.

In a statement, Professor Rodolf Tauber from the Charite clinic said: "This is an interesting case for research.

"But to promise to millions of people infected with HIV that there is hope of a cure would not be right."

Roughly one in 1,000 Europeans and Americans have an inherited genetic mutation, which prevents HIV from attaching itself to cells.

Two million people die of Aids every year and HIV is estimated to have infected 33 million people worldwide.

Option 'for a few'

Professor Andrew Sewell, from the Department of Medical Biochemistry and Immunology at the University of Cardiff said in theory a bone marrow transplant such as this one "should work" and it was surprising that no one had tried it before.

"The problem is most people with HIV live in sub-Saharan Africa and this is hugely expensive, you have to find a matched donor, and it's a pretty severe and painful operation.

"So it's going to be an option for very few people."

He added that gene therapy to knock out the mutation of the key CCR5 receptor was a possibility for future treatment.

Professor Philip Goulder, an immunologist at the University of Oxford said: "It's a really interesting case which looks at a treatment which really hasn't been thought about before.

"But without having that much information about the specific case you would want to be very cautious about getting too excited and you wouldn't be able to replicate that treatment for a lot of people with HIV."

Paul Ward, deputy chief executive at the Terrence Higgins Trust said: "This case gives us something to explore in future studies but it's certainly not a quick fix as gene therapy is complex and expensive.

"With no cure in sight, prevention should be our number one priority."

taken from: http://news.bbc.co.uk/2/hi/health/7726118.stm

Monday, November 17, 2008

One man's solution to handling his overdue account - really funny

From: Jane Gilles
Date: Wednesday 8 Oct 2008 12.19pm
To: David Thorne
Subject: Overdue account

Dear David,
Our records indicate that your account is overdue by the amount of $233.95. If you have already made this payment please contact us within the next 7 days to confirm payment has been applied to your account and is no longer outstanding.

Yours sincerely, Jane Gilles



From: David Thorne
Date: Wednesday 8 Oct 2008 12.37pm
To: Jane Gilles
Subject: Re: Overdue account

Dear Jane,
I do not have any money so am sending you this drawing I did of a spider instead. I value the drawing at $233.95 so trust that this settles the matter.

Regards, David

From: Jane Gilles
Date: Thursday 9 Oct 2008 10.07am
To: David Thorne
Subject: Overdue account

Dear David,
Thankyou for contacting us. Unfortunately we are unable to accept drawings as payment and your account remains in arrears of $233.95. Please contact us within the next 7 days to confirm payment has been applied to your account and is no longer outstanding.

Yours sincerely, Jane Gilles



From: David Thorne
Date: Thursday 9 Oct 2008 10.32am
To: Jane Gilles
Subject: Re: Overdue account

Dear Jane,
Can I have my drawing of a spider back then please.

Regards, David.
From: Jane Gilles
Date: Thursday 9 Oct 2008 11.42am
To: David Thorne
Subject: Re: Re: Overdue account

Dear David,
You emailed the drawing to me. Do you want me to email it back to you?

Yours sincerely, Jane Gilles



From: David Thorne
Date: Thursday 9 Oct 2008 11.56am
To: Jane Gilles
Subject: Re: Re: Re: Overdue account

Dear Jane,

Yes please.

Regards, David.
From: Jane Gilles
Date: Thursday 9 Oct 2008 12.14pm
To: David Thorne
Subject: Re: Re: Re: Re: Overdue account

Attached

From: David Thorne
Date: Friday 10 Oct 2008 09.22am
To: Jane Gilles
Subject: Whose spider is that?

Dear Jane,
Are you sure this drawing of a spider is the one I sent you? This spider only has seven legs and I do not feel I would have made such an elementary mistake when I drew it.

Regards, David.
From: Jane Gilles
Date: Friday 10 Oct 2008 11.03am
To: David Thorne
Subject: Re: Whose spider is that?

Dear David,
Yes it is the same drawing. I copied and pasted it from the email you sent me on the 8th. David your account is still overdue by the amount of $233.95. Please make this payment as soon as possible.

Yours sincerely, Jane Gilles



From: David Thorne
Date: Friday 10 Oct 2008 11.05am
To: Jane Gilles
Subject: Automated Out of Office Response

Thankyou for contacting me. I am currently away on leave, traveling through time and will be returning last week.

Regards, David.



From: David Thorne
Date: Friday 10 Oct 2008 11.08am
To: Jane Gilles
Subject: Re: Re: Whose spider is that?

Hello, I am back and have read through your emails and accept that despite missing a leg, that drawing of a spider may indeed be the one I sent you. I realise with hindsight that it is possible you rejected the drawing of a spider due to this obvious limb ommission but did not point it out in an effort to avoid hurting my feelings. As such, I am sending you a revised drawing with the correct number of legs as full payment for any amount outstanding. I trust this will bring the matter to a conclusion.

Regards, David.



From: Jane Gilles
Date: Monday 13 Oct 2008 2.51pm
To: David Thorne
Subject: Re: Re: Re: Whose spider is that?

Dear David,
As I have stated, we do not accept drawings in lei of money for accounts outstanding. We accept cheque, bank cheque, money order or cash. Please make a payment this week to avoid incurring any additional fees.

Yours sincerely, Jane Gilles



From: David Thorne
Date: Monday 13 Oct 2008 3.17pm
To: Jane Gilles
Subject: Re: Re: Re: Re: Whose spider is that?

I understand and will definately make a payment this week if I remember. As you have not accepted my second drawing as payment, please return the drawing to me as soon as possible. It was silly of me to assume I could provide you with something of completely no value whatsoever, waste your time and then attach such a large amount to it.

Regards, David.
From: Jane Gilles
Date: Tuesday 14 Oct 2008 11.18am
To: David Thorne
Subject: Re: Re: Re: Re: Re: Whose spider is that?

Attached





click here for the original site that featured this.

Thursday, November 13, 2008

Current state of affairs in the US for the average citizen

video

While this is pretty funny it is also somewhat profound, take a look.

Wednesday, November 12, 2008

RocknRolla


Guy Ritchie's newest movie... saw it last night... This one is FIRE, you definitely gotta check it out.
you will definitely love it!

Check out the official website for trailers and other info.

Monday, November 3, 2008

i caught a pic on the south florida New Times magazine

here's the pic from the exhibition, click to see the one b4 and the one after.. to see a few of my friends that attended:

http://www.browardpalmbeach.com/slideshow/view/166245/27

it's from the show at the Bear & Bird Gallery